Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine
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چکیده
منابع مشابه
Behavioral Disturbances Associated with Hyperdopaminergia in Dopamine-Transporter Knockout Mice
Mice lacking the dopamine transporter (DAT-/-) are characterized by high extracellular dopamine levels and spontaneous hyperlocomotion. We performed a detailed analysis of the behavioral phenotype of DAT-/mice in order to identify other behavioral impairments associated with the hyperdopaminergic tone of these mutant mice. In particular, we investigated locomotor activity, exploration, social a...
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OF TALK The monoaminergic neurotransmitter dopamine (DA) has been implicated in multiple brain disorders including schizophrenia, attention deficit hyperactivity disorder (ADHD), addiction and Parkinson's disease. Dopamine transporter (DAT) is a major regulator of both the intensity of extracellular dopamine (DA) signaling and presynaptic neuronal homeostasis. By deleting the gene encoding the ...
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this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
Increased rewarding properties of morphine in dopamine-transporter knockout mice.
The activation of dopamine (DA) neurotransmission plays a crucial role in the behavioural responses to drugs of abuse. In particular, increased extracellular levels of DA within the mesolimbic pathway have been implicated in the rewarding and locomotor stimulatory properties of morphine. We investigated the behavioural responses to morphine in mice with a genetic disruption of the DA transporte...
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Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA(A) receptor signaling by its metabolites. It has been shown that the level of pregnenolone is altered in certain brain areas of schizophrenic patients, and clozapine enhances pregnenolone in the CNS in rats, suggesting that pregnen...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2013
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2012.07.016